Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs

Polymeric biomaterials for the delivery of platinum-based anticancer drugs.

Since cisplatin, cis-diamminedichloroplatinum(ii), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck. However, there are concerns associated with the use of platinum-based anticancer drugs, owing to severe side effects and drug resistance. In order to overco...

synthesis of chitosan oligomer conjugated methotrexate nanomicells for purpose of co-delivery of anticancer drugs

Smart Polymeric Nanoparticles for Cancer Gene Delivery

The massive amount of human genetic information already available has accelerated the identification of target genes, making gene and nucleic acid therapy the next generation of medicine. Nanoparticle (NP)-based anticancer gene therapy treatment has received significant interest in this evolving field. Recent advances in vector technology have improved gene transfection efficiencies of nonviral...

Polymeric Drugs: A Novel Approach to Drug Delivery System

This review article describes the current status and recent advances of polymeric drugs with regard to their application in drug delivery system. Essentially polymer-drug conjugation aims to achieve improved drug targeting, decrease drug toxicity and overcome mechanisms of drug resistance. First generation conjugates used linear monomethoxy PEGs and other linear polymers. Modern polymeric chemi...

Antibacterial and Anticancer Drugs - Interaction with DNA